You might run into issues if your system is missing some important updates. If this trick doesn’t give you luck, check out the next one below. Or you can move everything on your Desktop to another drive and see if NVIDIA Control Panel works now. According to the feedback, you can check and move any files or folders with a lengthy name. It might sound strange, but some users reported that the culprit was some files/folders on their Desktop. If this method doesn’t work for you, simply continue to the next one below. Right click nvcplui.exe and select Run as administrator.On your keyboard, press Win+R (the Windows logo key and the R key) and type or paste C:\Program Files\NVIDIA Corporation\Control Panel Client.
Instead of opening via the Desktop shortcut, you need to run NVIDIA Control Panel in the installation folder.